---
name: 4basebio
slug: 4basebio
site: cdmo
website_domain: 4basebio.com
summary: 4basebio manufactures high-quality synthetic DNA and RNA using proprietary cell-free amplification technology, supporting mRNA vaccines, viral vectors, gene editing, and cell/gene therapies from research through GMP-grade clinical production. Headquartered in Over, United Kingdom.
tagline: Synthetic DNA and RNA CDMO for next-generation genetic medicines, from research to clinical production.
founded_year: 
employee_count_band: 
employee_count_label: 
parent_name: 
parent_slug: 
hq_country: GB
tier2_domain_verified: false
updated_at: 2026-08-27T00:01:47.057Z
services_count: 7
modalities_count: 3
indications_count: 0
locations_count: 3
review_signal_gate: closed
generated_by: BioBM Editorial AI
---

# 4basebio

Synthetic DNA and RNA CDMO for next-generation genetic medicines, from research to clinical production.

Listed on cdmo.directory.

## Summary

4basebio manufactures high-quality synthetic DNA and RNA using proprietary cell-free amplification technology, supporting mRNA vaccines, viral vectors, gene editing, and cell/gene therapies from research through GMP-grade clinical production. Headquartered in Over, United Kingdom.

## At a glance

- HQ country: GB

## Services

- CMC Analytical Development
- Process Development
- Formulation Development
- mRNA Manufacturing
- Viral Vector Manufacturing
- Lipid Nanoparticle (LNP) Formulation
- Cell-Line Development

## Modalities

- mRNA
- AAV / Viral Vector Platform
- Gene Therapy

## Locations

- Headquarters and R&D, Over, Cambridge, United Kingdom
- GMP Manufacturing Facility, Swavesey, Cambridge, United Kingdom
- Enzyme Manufacturing Facility, Madrid, Madrid, Spain

## Certifications

- UK GMP; Identifier: GMP-licensed; Source: https://4basebio.com/manufacturing

## Long description

## Overview

4basebio is a specialist CDMO providing synthetic DNA and RNA manufacturing services for next-generation genetic medicines. The company operates a GMP-licensed manufacturing facility near Cambridge, UK, and a dedicated enzyme manufacturing facility in Madrid, Spain.

## Core Capabilities

**Synthetic DNA Manufacturing:**
- Cell-free DNA amplification technology as an alternative to plasmid DNA (pDNA)
- Available in RUO, HQ, and GMP-grade formats
- opDNA® for mRNA vaccines and therapeutics
- hpDNA for viral vector production and DNA vaccines
- ssDNA for gene editing applications
- Eliminates bacterial sequences, host-cell contaminants, and antibiotic resistance genes
- 4x faster production compared to pDNA with enhanced purity

**RNA Services:**
- mRNA manufacturing derived from synthetic DNA templates
- saRNA manufacturing
- Comprehensive manufacturing services with precise control over each development stage

**Formulation & Delivery:**
- Hermes® nanoparticle platform for DNA and RNA delivery
- LNP formulation services enabling continuous link between DNA template production, RNA synthesis, and encapsulation

## Applications Supported

- mRNA vaccines and therapeutics
- Viral vector manufacturing (AAV and other vectors)
- Gene editing platforms
- DNA vaccines
- Personalized cancer therapies
- Non-viral delivery systems
- Cell and gene therapies

## Regulatory & Quality

- GMP-licensed manufacturing facility at Buckingway Business Park, Swavesey, Cambridge
- Purpose-built cleanrooms and advanced quality control systems
- In-house enzyme manufacturing ensures supply chain control and consistency
- Regulatory expertise in process development and compliance
- Demonstrated FDA IND approval support (Tier 1 pharma partner mRNA product in Phase I/II clinical trial as of October 2025)

## Manufacturing Scale

Capabilities span from early-stage research-grade production through full-scale GMP manufacturing, with dedicated support teams worldwide for process development, regulatory compliance, and project management.

## Related companies

- [Vernal Biosciences](/companies/vernal) (CMC Analytical Development, Process Development) — [Compare](/compare/4basebio/vernal)
- [Biomay AG](/companies/biomay) (CMC Analytical Development, Process Development) — [Compare](/compare/4basebio/biomay)
- [Porton Advanced](/companies/porton-advanced) (CMC Analytical Development, Process Development) — [Compare](/compare/4basebio/porton-advanced)
- [Creative Biogene](/companies/creative-biogene) (CMC Analytical Development, mRNA Manufacturing) — [Compare](/compare/4basebio/creative-biogene)
- [ElevateBio](/companies/elevate) (CMC Analytical Development, Process Development) — [Compare](/compare/4basebio/elevate)
- [Aldevron](/companies/aldevron) (CMC Analytical Development, Process Development) — [Compare](/compare/4basebio/aldevron)
- [eXmoor Pharma](/companies/exmoorpharma) (CMC Analytical Development, Process Development) — [Compare](/compare/4basebio/exmoorpharma)
- [AskBio](/companies/askbio) (CMC Analytical Development, Process Development) — [Compare](/compare/4basebio/askbio)

_Profile last updated: 2026-08-27T00:01:47.057Z. Profile facts may include AI-assisted enrichment._

Auto-generated by BioBM Editorial AI for machine-readable profile access.