--- name: Asimov slug: asimov site: cdmo website_domain: asimov.com summary: Asimov provides cell line development, upstream process development, and viral vector manufacturing services powered by proprietary synthetic biology platforms (CHO Edge, LV Edge, AAV Edge, RNA Edge) that deliver high-titer, stable cell lines and production systems for biologics, cell therapies, and gene therapies. Headquartered in Boston, United States. tagline: Synthetic biology platform for high-titer cell line development and viral vector manufacturing. founded_year: employee_count_band: employee_count_label: parent_name: parent_slug: hq_country: US tier2_domain_verified: false updated_at: 2026-10-03T00:03:53.713Z services_count: 11 modalities_count: 5 indications_count: 0 locations_count: 1 review_signal_gate: closed generated_by: BioBM Editorial AI --- # Asimov Synthetic biology platform for high-titer cell line development and viral vector manufacturing. Listed on cdmo.directory. ## Summary Asimov provides cell line development, upstream process development, and viral vector manufacturing services powered by proprietary synthetic biology platforms (CHO Edge, LV Edge, AAV Edge, RNA Edge) that deliver high-titer, stable cell lines and production systems for biologics, cell therapies, and gene therapies. Headquartered in Boston, United States. ## At a glance - HQ country: US ## Services - CMC Analytical Development - Technology Transfer - Lentiviral Vector Manufacturing - AAV Manufacturing - Viral Vector Manufacturing - Monoclonal Antibody (mAb) Manufacturing - Recombinant Protein Manufacturing - Biologics Development & Manufacturing - Cell-Line Development - Upstream Processing - Process Development ## Modalities - Biologics (Monoclonal Antibodies) - Biologics (Other) - Gene Therapy - Cell Therapy - mRNA ## Locations - Headquarters, Boston, MA, USA ## Long description ## Overview Asimov is a synthetic biology company offering contract cell line development (CLD) and upstream process development services for therapeutic biologics, cell therapies, and gene therapies. The company combines proprietary genetic engineering tools, cloud-based design software (Kernel), and GMP-grade host cell lines to enable clients to develop high-performance producer cell lines. ## Core Service Offerings ### Cell Line Development (CHO Edge System) - Develops stable CHO-based cell lines for monoclonal antibodies and other biologics - Typical titers of 8–11 g/L or higher across modalities - Guarantees minimum 5 g/L for mAb IgG; if below threshold, CLD campaign and commercial-use rights are free - Timeline: ~4 months from sequence to research cell bank delivery - Includes in-house analytical development for product characterization - Monoclonality verification via Cytena F-sight and Solentim Cell Metric imaging - Fed-batch scale-up using Ambr 15 and Ambr 250 bioreactors - Delivers clonal cell banks with CMC-compliant documentation and platform process for tech transfer ### Lentiviral Vector Production (LV Edge System) - Off-the-shelf LV Edge Packaging cell line achieving titers exceeding traditional transient transfection - Single-plasmid transfection system (vs. standard four-plasmid process) - Reduces GMP plasmid cost, process complexity, and supply chain risk - Licensed to AGC Biologics' Cell and Gene Center of Excellence in Milan for commercial manufacturing - Engineered HEK293 cell line with inducible viral genes and supporting software ### AAV Vector Production (AAV Edge System) - End-to-end payload design and gene therapy production tools - Achieves titers up to 6E15 vg/L ### RNA Therapeutics (RNA Edge System) - Sequence design through wet lab validation in weeks - Delivers high-confidence candidates ## Technology Platform **Kernel Software:** Cloud-based design and optimization tool for genetic constructs, codon optimization, vector design, and biophysical simulation across different cell types. **Genetic Parts Library:** Over 1,000 experimentally validated genetic parts including transposases, expression vectors, inducible systems, and tissue-specific promoters. **Host Cell Lines:** Engineered, GMP-banked host cells with regulatory documentation for therapeutic applications. **Proprietary Transposase:** Drives >80% titer stability over 75 generations in stable clones. ## Engagement Models Asimov offers flexible collaboration options: - **Full service:** Client provides sequence; Asimov performs CLD and process development in-house, delivering clonal cell banks and tech-transfer documentation - **Hybrid:** Client uses Asimov software and host cells to perform in-house CLD with technical support - **Tools only:** Client receives software access, DNA constructs, and GMP host cells for independent development ## Regulatory & Quality - CMC-compliant documentation provided with cell banks - Platform processes designed for regulatory filing - Team comprises scientists with combined decades of experience developing clinical-grade cell lines - Collaborations with established CDMOs (e.g., AGC Biologics) for manufacturing scale-up ## Research & Development - DARPA ASKE (Automating Scientific Knowledge Extraction) contract awardee for developing physics-based AI design engine for biology - Focus on multi-omics cellular measurements, structured biological metadata, and hybrid AI architectures (deep learning, reinforcement learning, mechanistic modeling) ## Related companies - [AGC Biologics](/companies/agcbio) (CMC Analytical Development, Technology Transfer) — [Compare](/compare/agcbio/asimov) - [Charles River Laboratories](/companies/criver) (CMC Analytical Development, Technology Transfer) — [Compare](/compare/asimov/criver) - [Minaris Advanced Therapies](/companies/wuxi-advanced-therapies) (CMC Analytical Development, Technology Transfer) — [Compare](/compare/asimov/wuxi-advanced-therapies) - [FUJIFILM Biotechnologies](/companies/fujifilm-biotechnologies) (CMC Analytical Development, Technology Transfer) — [Compare](/compare/asimov/fujifilm-biotechnologies) - [Avid Bioservices](/companies/avidbio) (CMC Analytical Development, Technology Transfer) — [Compare](/compare/asimov/avidbio) - [Creative Biolabs](/companies/creativebiolabs) (CMC Analytical Development, Monoclonal Antibody (mAb) Manufacturing) — [Compare](/compare/asimov/creativebiolabs) - [Celonic](/companies/celonic) (CMC Analytical Development, Technology Transfer) — [Compare](/compare/asimov/celonic) - [Andelyn Biosciences](/companies/andelynbio) (CMC Analytical Development, Technology Transfer) — [Compare](/compare/andelynbio/asimov) _Profile last updated: 2026-10-03T00:03:53.713Z. 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