---
name: Biospring
slug: biospring
site: cdmo
website_domain: biospring.net
summary: Global CDMO leader in nucleic acid manufacturing and analysis (mRNA, ASO, siRNA, guide RNA, oligonucleotides) with nearly three decades of expertise, GMP certification since 2007, and support for 9 commercial programs across all clinical phases.
tagline: Global nucleic acid CDMO with three decades of expertise in mRNA, ASO, siRNA, and oligonucleotide manufacturing.
founded_year: 1997
employee_count_band: 
employee_count_label: 
parent_name: 
parent_slug: 
hq_country: 
tier2_domain_verified: false
updated_at: 2026-08-02T07:02:03.278Z
services_count: 8
modalities_count: 2
indications_count: 0
locations_count: 1
review_signal_gate: closed
generated_by: BioBM Editorial AI
---

# Biospring

Global nucleic acid CDMO with three decades of expertise in mRNA, ASO, siRNA, and oligonucleotide manufacturing.

Listed on cdmo.directory.

## Summary

Global CDMO leader in nucleic acid manufacturing and analysis (mRNA, ASO, siRNA, guide RNA, oligonucleotides) with nearly three decades of expertise, GMP certification since 2007, and support for 9 commercial programs across all clinical phases.

## At a glance

- Founded: 1997

## Services

- mRNA Manufacturing
- Oligonucleotide Manufacturing
- CMC Analytical Development
- Process Development
- Technology Transfer
- CMC Regulatory Submission Support
- Stability Testing & Storage
- Quality Control Testing

## Modalities

- mRNA
- Oligonucleotide

## Locations

- Headquarters

## Certifications

- GMP; Identifier: GMP certified since 2007; Source: https://biospring.net/
- FDA; Identifier: FDA inspected; Source: https://biospring.net/de/manufacturing-services/manufacturing-grades/cgmp-commercial
- ANVISA; Identifier: ANVISA inspected; Source: https://biospring.net/de/manufacturing-services/manufacturing-grades/cgmp-commercial

## Long description

## Overview

BioSpring is a specialized CDMO focused exclusively on nucleic acid therapeutics manufacturing and analytical services. Founded in 1997, the company has established itself as a global leader in oligonucleotide and mRNA production, serving pharmaceutical and biotech companies, and academic institutions worldwide.

## Manufacturing Services

BioSpring offers end-to-end manufacturing solutions across all development stages:

- **Research Grade**: μg to multi-gram scale production for early discovery, lead screening, and lead optimization
- **Preclinical**: Pre-GMP quality nucleic acids for preclinical development
- **Clinical (cGMP)**: GMP-compliant manufacturing for IND-enabling and clinical trial materials
- **Commercial (cGMP)**: Full-scale commercial production with proven track record supporting 9 marketed oligonucleotide programs

The company manufactures a comprehensive range of nucleic acid modalities including antisense oligonucleotides (ASOs), guide RNAs (gRNA), messenger RNA (mRNA), small interfering RNA (siRNA), CpG ODNs, and other specialized oligonucleotides.

## Analytical Services

Comprehensive analytical support includes bioanalytical services, characterization, method development and transfer, method validation, and release and stability testing for both drug substance and drug product.

## Integrated Services

BioSpring provides project management, process development, and regulatory support including documentation for IND, IMPD, NDA, MAA, J-NDA, BLA, and DMF submissions. The company offers process validation, technology transfer, and post-market lifecycle management support.

## Quality & Regulatory

GMP certified since 2007 with FDA and ANVISA inspection history. The company combines advanced analytical solutions, continuous innovation in purification technologies, and comprehensive regulatory expertise to support clients from early development through commercial launch and post-market supply.

## Related companies

- [Hongene Biotech Corporation](/companies/hongene) (mRNA Manufacturing, Oligonucleotide Manufacturing) — [Compare](/compare/biospring/hongene)
- [TriLink BioTechnologies](/companies/trilinkbiotech) (mRNA Manufacturing, Oligonucleotide Manufacturing) — [Compare](/compare/biospring/trilinkbiotech)
- [CPC Scientific](/companies/cpcscientific) (Oligonucleotide Manufacturing, CMC Analytical Development) — [Compare](/compare/biospring/cpcscientific)
- [Bachem](/companies/bachem) (Oligonucleotide Manufacturing, CMC Analytical Development) — [Compare](/compare/bachem/biospring)
- [Maravai LifeSciences](/companies/maravai) (mRNA Manufacturing, Oligonucleotide Manufacturing) — [Compare](/compare/biospring/maravai)
- [Sophia CDMO](/companies/sophiacdmo) (mRNA Manufacturing, Oligonucleotide Manufacturing) — [Compare](/compare/biospring/sophiacdmo)
- [Glatt](/companies/glatt) (CMC Analytical Development, Process Development) — [Compare](/compare/biospring/glatt)
- [MyBiotech GmbH](/companies/mybiotech) (CMC Analytical Development, Process Development) — [Compare](/compare/biospring/mybiotech)

_Profile last updated: 2026-08-02T07:02:03.278Z. Profile facts may include AI-assisted enrichment._

Auto-generated by BioBM Editorial AI for machine-readable profile access.