---
name: Flamma
slug: flammagroup
site: cdmo
website_domain: flammagroup.com
summary: Privately held small molecule CDMO with FDA-inspected cGMP facilities in Italy, USA, and China, offering custom manufacturing, development, and specialized technologies including HPAPI, continuous flow, and cryogenic API synthesis from early-stage to commercial scale. Headquartered in Chignolo d'Isola, Italy.
tagline: Small molecule CDMO securing pharma supply chains across Italy, USA, and China since 1950.
founded_year: 1950
employee_count_band: 
employee_count_label: 
parent_name: 
parent_slug: 
hq_country: IT
tier2_domain_verified: false
updated_at: 2026-09-09T07:02:27.912Z
services_count: 9
modalities_count: 1
indications_count: 0
locations_count: 7
review_signal_gate: closed
generated_by: BioBM Editorial AI
---

# Flamma

Small molecule CDMO securing pharma supply chains across Italy, USA, and China since 1950.

Listed on cdmo.directory.

## Summary

Privately held small molecule CDMO with FDA-inspected cGMP facilities in Italy, USA, and China, offering custom manufacturing, development, and specialized technologies including HPAPI, continuous flow, and cryogenic API synthesis from early-stage to commercial scale. Headquartered in Chignolo d'Isola, Italy.

## At a glance

- Founded: 1950
- HQ country: IT

## Services

- HPAPI Manufacturing (High-Potency)
- Flow Chemistry & Continuous Manufacturing
- Solid-State Chemistry & Polymorph Screening
- API Synthesis & Manufacturing
- Process Development
- Formulation Development
- CMC Analytical Development
- Technology Transfer
- CMC Regulatory Submission Support

## Modalities

- Small Molecule

## Locations

- Headquarters, Chignolo d'Isola, Bergamo, Italy
- Isso, Isso, Lombardy, Italy
- Bulciago, Bulciago, Lombardy, Italy
- Dalian, Dalian, Liaoning, China
- Malvern, Malvern, Pennsylvania, USA
- Boston, Boston, Massachusetts, USA
- Paris, Paris, Île-de-France, France

## Certifications

- FDA; Identifier: cGMP inspected; Source: https://flammagroup.com/

## Long description

## Overview

Flamma is a privately held, family-run CDMO with over 70 years of experience (founded 1950) specializing in small molecule Active Pharmaceutical Ingredients (APIs), New Chemical Entities (NCEs), Registered Starting Materials (RSMs), and Key Intermediates. The company operates a global supply chain with FDA-inspected cGMP facilities in Italy, a GMP site in the USA, and a 100% owned and operated GMP facility in China.

## Core Capabilities

- **Custom Manufacturing** — full-scale production from early-stage to commercial delivery
- **Custom Development** — process optimization and scale-up support
- **cGMP Manufacturing** — compliant production across multiple geographies

## Specialized Technologies

- **Highly Potent API (HPAPI)** — dedicated manufacturing for potent compounds
- **Continuous Flow Chemistry** — advanced flow-based synthesis
- **Cryogenic (Low Temperature) API Manufacturing** — specialized low-temp processes
- **Crystallization Research & Solid State Chemistry** — polymorph screening and characterization
- **Common Technologies** — standard synthetic routes and scale-up

## Recognition

Flamma has received multiple industry awards, including recognition as a Top 10 CMO in Europe by Pharma Tech Outlook. The company was the only small molecule CDMO rated as a TOP PERFORMER in all 6 CDMO Core Award Categories (Expertise, Reliability, Capabilities, Quality, Service, Compatibility) and all 7 Specialty Award Categories (Accessible Senior Management, State-of-the-Art, Innovation, On-Time Delivery, Right the First Time, Strength of Science, Reputation) in the CDMO Leadership Award evaluation of 110 CDMOs.

## Facilities

Flamma operates multiple production and development sites across three continents, enabling flexible supply chain management and regulatory compliance across major markets.

## Related companies

- [Axplora](/companies/axplora) (HPAPI Manufacturing (High-Potency), Flow Chemistry & Continuous Manufacturing) — [Compare](/compare/axplora/flammagroup)
- [Cambrex](/companies/cambrex) (HPAPI Manufacturing (High-Potency), Flow Chemistry & Continuous Manufacturing) — [Compare](/compare/cambrex/flammagroup)
- [PharmaBlock](/companies/pharmablock) (Flow Chemistry & Continuous Manufacturing, Solid-State Chemistry & Polymorph Screening) — [Compare](/compare/flammagroup/pharmablock)
- [Laurus Labs](/companies/lauruslabs) (API Synthesis & Manufacturing, Process Development) — [Compare](/compare/flammagroup/lauruslabs)
- [SEQENS](/companies/seqens) (Flow Chemistry & Continuous Manufacturing, API Synthesis & Manufacturing) — [Compare](/compare/flammagroup/seqens)
- [Sai Life Sciences](/companies/sailife) (Flow Chemistry & Continuous Manufacturing, Solid-State Chemistry & Polymorph Screening) — [Compare](/compare/flammagroup/sailife)
- [CMC Pharmaceuticals, Inc.](/companies/cmcpharm) (HPAPI Manufacturing (High-Potency), API Synthesis & Manufacturing) — [Compare](/compare/cmcpharm/flammagroup)
- [Dipharma](/companies/dipharma) (API Synthesis & Manufacturing, Process Development) — [Compare](/compare/dipharma/flammagroup)

_Profile last updated: 2026-09-09T07:02:27.912Z. Profile facts may include AI-assisted enrichment._

Auto-generated by BioBM Editorial AI for machine-readable profile access.