---
name: Macrocyclics, Inc.
slug: macrocyclics
site: cdmo
website_domain: macrocyclics.com
summary: Chelator-focused CDMO for radiopharmaceuticals, offering cGMP clinical-trial manufacture, custom synthesis scaled to kilogram quantities, bioconjugation, and HPLC/Q-TOF analytical testing.
tagline: Chelating agents and cGMP services for radiopharmaceutical development
founded_year: 
employee_count_band: 
employee_count_label: 
parent_name: 
parent_slug: 
hq_country: 
tier2_domain_verified: false
updated_at: 2026-11-12T07:00:51.620Z
services_count: 5
modalities_count: 3
indications_count: 1
locations_count: 0
review_signal_gate: closed
generated_by: BioBM Editorial AI
---

# Macrocyclics, Inc.

Chelating agents and cGMP services for radiopharmaceutical development

Listed on cdmo.directory.

## Summary

Chelator-focused CDMO for radiopharmaceuticals, offering cGMP clinical-trial manufacture, custom synthesis scaled to kilogram quantities, bioconjugation, and HPLC/Q-TOF analytical testing.

## Services

- API Synthesis & Manufacturing
- Small Molecule Development & Manufacturing
- Bioconjugation Services
- Analytical Method Development & Validation
- Peptide Manufacturing

## Modalities

- Radiopharmaceutical
- Small Molecule
- Peptide

## Indications

- Oncology

## Long description

Macrocyclics, Inc. describes itself as a CDMO specializing in chelating agents for radiopharmaceuticals and nuclear medicine.

## Services

- **cGMP for Clinical Trials:** GMP production of chelating agents, labeling precursors, and small molecule APIs. Projects begin with a quote request and proceed through questions, experiments, and protocols.
- **Custom Organic Synthesis:** Synthesis for linker mechanisms, drug conjugates, and labeling precursors. Labs are set up for small, multi-milligram projects, with equipment for multi-gram to kilogram scale-up.
- **Bioconjugation:** Multiple conjugation mechanisms targeting random lysine residues, interchain cysteine, and enzymatic tags, supported by in-house analytical instruments.
- **Analytical Testing:** HPLC and HRMS (Q-TOF) proficiencies, supporting stability extensions, impurity elucidation, and structural confirmation.

## Facilities

The company operates a newer facility with chemistry and biological laboratories and a radiochemistry lab licensed for popular PET imaging and therapeutic radionuclides. Listed capabilities include peptide synthesis, a dedicated radioisotope hot-lab, and two analytical laboratories with UPLC, QTOF, CE, FTIR, and polarimetry.

## Product catalog

The site also sells bifunctional chelators, conjugates, macrocyclic ligands, and related reagents, including Macropa for Ac-225.

## Related companies

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_Profile last updated: 2026-11-12T07:00:51.620Z. Profile facts may include AI-assisted enrichment._

Auto-generated by BioBM Editorial AI for machine-readable profile access.