Sussex Research Laboratories Inc.

Overview

Sussex Research Laboratories Inc. is a specialized contract research and manufacturing organization focused on glycoscience—the study of carbohydrates (glycans) and their roles in biological processes. The company serves as a global leader in carbohydrate synthesis, offering both custom synthesis services and an extensive portfolio of pre-made glycan-based products.

Core Services

Glycan Synthesis & Development

• Scalable, cost-effective synthesis of simple modified monosaccharides (e.g., GalNAc targeting ligands) to complex oligosaccharides (e.g., Sialyl Lewis X)
• Expertise in hepatic (GalNAc) and extra-hepatic drug delivery strategies
• Support for oligonucleotide, protein, lipid, and small-molecule-based applications

Glycopeptides & Peptides

• Over 20 years of leadership in glycopeptide synthesis
• Synthetic tumor-associated carbohydrate antigens (TACA) based on mucins, PSGL-1 mimetics, and glycopolypeptides
• World's largest inventory of well-defined glycoamino acid building blocks
• Expertise in glycated (fructosylated), glycolipid, lipid, and macrocyclic peptides

Antibody Development

• Carbohydrate-based antigen production for antibody screening and generation
• Glycan, glycopeptide, and glycolipid antigens with BSA, OVA, CRM, or KLH carrier protein conjugates

Targeting Ligands

• Cell-specific carbohydrate ligands (GalNAc, sialic acid-containing glycans) targeting lectin/carbohydrate-mediated drug delivery
• Receptor targeting: ASGPR, Galectins, Siglecs, Mannose-6-phosphate Receptor, Influenza HAs, Mannose Receptor (CD206)
• Applications in RNA and difficult therapeutic molecule delivery to specific tissues

Preclinical & GMP Manufacturing Support

• Connection to trusted network for pre-clinical and GMP manufacturing scale-up
• Transition support from development to large-scale production

Quality & Compliance

• ISO 9001:2015 certified
• Rigorous quality control protocols throughout synthesis
• Certificate of Analysis and analytical data documentation provided

Market Position

• Over 1,000 clients worldwide
• Over 25 years of industry experience
• Made in Canada with international recognition
• Expertise honed over decades in glycoscience research