4basebio

Overview

4basebio is a specialist CDMO providing synthetic DNA and RNA manufacturing services for next-generation genetic medicines. The company operates a GMP-licensed manufacturing facility near Cambridge, UK, and a dedicated enzyme manufacturing facility in Madrid, Spain.

Core Capabilities

Synthetic DNA Manufacturing:

• Cell-free DNA amplification technology as an alternative to plasmid DNA (pDNA)
• Available in RUO, HQ, and GMP-grade formats
• opDNA® for mRNA vaccines and therapeutics
• hpDNA for viral vector production and DNA vaccines
• ssDNA for gene editing applications
• Eliminates bacterial sequences, host-cell contaminants, and antibiotic resistance genes
• 4x faster production compared to pDNA with enhanced purity

RNA Services:

• mRNA manufacturing derived from synthetic DNA templates
• saRNA manufacturing
• Comprehensive manufacturing services with precise control over each development stage

Formulation & Delivery:

• Hermes® nanoparticle platform for DNA and RNA delivery
• LNP formulation services enabling continuous link between DNA template production, RNA synthesis, and encapsulation

Applications Supported

• mRNA vaccines and therapeutics
• Viral vector manufacturing (AAV and other vectors)
• Gene editing platforms
• DNA vaccines
• Personalized cancer therapies
• Non-viral delivery systems
• Cell and gene therapies

Regulatory & Quality

• GMP-licensed manufacturing facility at Buckingway Business Park, Swavesey, Cambridge
• Purpose-built cleanrooms and advanced quality control systems
• In-house enzyme manufacturing ensures supply chain control and consistency
• Regulatory expertise in process development and compliance
• Demonstrated FDA IND approval support (Tier 1 pharma partner mRNA product in Phase I/II clinical trial as of October 2025)

Manufacturing Scale

Capabilities span from early-stage research-grade production through full-scale GMP manufacturing, with dedicated support teams worldwide for process development, regulatory compliance, and project management.