AM Chemicals LLC

AM Chemicals is a supplier of solid supports and reagents for oligonucleotide synthesis, established in 2003. The company manufactures universal solid supports and phosphoramidite reagents that enable efficient DNA and RNA oligonucleotide synthesis. AM Chemicals also offers custom radiolabeling services, synthesizing ¹⁴C, ³⁵S, and ³H radiolabeled oligonucleotides and their phosphorothioate analogs at scales from 1 to 100 µmol. Services include synthesis of radiolabeled phosphoramidite building blocks, HPLC purification (reverse-phase or ion-exchange), desalting, and optional GMP manufacturing. The company can incorporate functional groups such as GalNAc, cholesteryl, and tocopherol at specified positions for cellular uptake optimization.