Synthego

Synthego is a biotechnology company specializing in CRISPR gene editing solutions and molecular diagnostics. The company operates dual business lines: research-grade products sold through catalog channels, and contract GMP manufacturing services for clinical-stage therapeutics.

GMP Manufacturing & Clinical Services:

• GMP gRNA (guide RNA) synthesis with demonstrated IND-enabling capability (19 INDs cleared)
• GMP CRISPR editors (SpCas9, AccuBase base editor, hfCas12Max) in protein and mRNA formats
• Custom nuclease manufacturing for clinical applications
• Regulatory expertise and IND submission support
• 200+ clinical sgRNA batches manufactured to date
• 40+ successful customer audits completed

Research & Molecular Biology Products:

• Synthetic gRNA and CRISPR nuclease research kits
• Cell-free protein expression systems
• Isothermal amplification (RPA) reagents and enzymes
• PCR, reverse transcription, and IVT enzymes
• Sample preparation and nucleic acid processing products
• CRISPR design and analysis tools (ICE platform)

Applications & Modalities:

• CRISPR gene editing (base editing, CAR-T cell therapy, iPSC engineering)
• Cell and gene therapy manufacturing support
• Molecular and clinical diagnostics workflows

The company serves both academic researchers and therapeutic developers, with particular strength in enabling early-stage CRISPR-based cell and gene therapy programs through GMP-compliant manufacturing and regulatory guidance.