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Macrocyclics, Inc.

Chelating agents and cGMP services for radiopharmaceutical development

Chelator-focused CDMO for radiopharmaceuticals, offering cGMP clinical-trial manufacture, custom synthesis scaled to kilogram quantities, bioconjugation, and HPLC/Q-TOF analytical testing.

Modalities

Development & manufacturing

Structured CDMO capabilities from verified public sources.

Manufacturing (M)

Synthetic chemistry infrastructure

Max chemical scale
Bench scale (<10 kg)

Services

Indications

About this organization

Macrocyclics, Inc. describes itself as a CDMO specializing in chelating agents for radiopharmaceuticals and nuclear medicine.

Services

  • cGMP for Clinical Trials: GMP production of chelating agents, labeling precursors, and small molecule APIs. Projects begin with a quote request and proceed through questions, experiments, and protocols.
  • Custom Organic Synthesis: Synthesis for linker mechanisms, drug conjugates, and labeling precursors. Labs are set up for small, multi-milligram projects, with equipment for multi-gram to kilogram scale-up.
  • Bioconjugation: Multiple conjugation mechanisms targeting random lysine residues, interchain cysteine, and enzymatic tags, supported by in-house analytical instruments.
  • Analytical Testing: HPLC and HRMS (Q-TOF) proficiencies, supporting stability extensions, impurity elucidation, and structural confirmation.

Facilities

The company operates a newer facility with chemistry and biological laboratories and a radiochemistry lab licensed for popular PET imaging and therapeutic radionuclides. Listed capabilities include peptide synthesis, a dedicated radioisotope hot-lab, and two analytical laboratories with UPLC, QTOF, CE, FTIR, and polarimetry.

Product catalog

The site also sells bifunctional chelators, conjugates, macrocyclic ligands, and related reagents, including Macropa for Ac-225.

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